The Afghan Defense Ministry said 36 militants were killed, though local officials and residents put the number much higher. An official Afghan government put the count at 36 ISIS fighter.
"Security source to Amaq agency denies any dead or wounded from yesterday's American strike in Achin district's Asadkhelo village using a GBU-43/B", the group's self-styled news agency said on social media accounts. That number is yet to be independently verified.
In another show of military force after the bombing of a Syrian airfield with 59 Tomahawk missiles, the U.S. military yesterday dropped a GBU-43/B, colloquially known as the Mother Of All Bombs or MOAB, to target caves built by Islamic State fighter in Nangarhar province of Afghanistan.
Thursday's explosion reverberated for kilometres and engulfed the remote area in towering flames, destroying what officials called a network of underground ISIS tunnels and caves that had been mined against conventional ground attacks.
Nangarhar police said that the bombing destroyed Daesh hideouts, tunnels and weapon caches.
The US military defended its decision when it was quizzed Friday on whether the 21,600-pound behemoth was necessary for that particular target.
"This was the first time that we encountered an extensive obstacle to our progress", he said on Friday of a joint Afghan-US operation that has been targeting IS since March.
US military authorities in Afghanistan estimate that ISIS could have up to 800 fighters in the country, with most operating in the remote eastern Nangarhar province.
The Afghan presidential palace said precautions were taken to avoid civilian casualties.
Former Afghan president Hamid Karzai on Saturday criticized both the Afghan and US governments for the attack in Nangarhar. "So we have incredible leaders of the military and incredible military, and we are very proud of them, and this was another very successful mission", Trump said.
The bombing triggered shock waves in Afghanistan.
This time last week we were talking about the launch of missiles in Syria.
Another Achin resident, Mohammad Hakim, approved of the strike. "It was an earsplitting blast", said Shah Wali, 46, who lives in the village of Goor Gari, 15 kilometres (9 miles) from the border with Nangarhar.
"We were all scared, and my children and my wife were crying". We thought it was an quake.
It did not provide any details on how many of these bombs exist.
Before the strike, CBS New correspondent David Martin says there were an estimated 600 to 800 ISIS fighters in Afghanistan.
"Still, from a strategic standpoint, there is an unsettling takeaway here: the U.S. pulled off a huge shock and awe mission against an enemy that isn't even the top threat to the United States in Afghanistan".