Diabetes drug reduces heart attack risk

The findings suggested canagliflozin reduced the risk of cardiovascular disease by 14 per cent and also lowered the risk of hospitalisation relating to heart failure by 33 per cent.

With coronary heart disease the biggest killer of people with type 2 diabetes, Australian researcher Professor Bruce Neal of The George Institute for Global Health says the findings offer real hope to the thousands of Australians with the disease.

The risk of amputations of toes or feet was double in patients who took Invokana compared with those who took placebo in studies that involved 10,142 type 2 diabetes patients.

Because these issues are strongly linked to type two diabetes, the drug could make a huge difference to the four million people in the United Kingdom who have the disease.

The new data comes from two separate trials and was presented at the American Diabetes Association (ADA) 2017 Scientific Sessions.

Metformin is now recommended for those with the condition to reduce insulin intake and stabilise weight, but its effects on the heart and blood vessels have been unknown. The findings were cited as particularly relevant to Australia where around 65%of cardiovascular deaths occur in people with diabetes or pre-diabetes, and diabetes is also the leading cause of end-stage kidney disease. But the new study reveals the £1.30 a day drug also has a remarkable impact on cardiovascular problems and kidney disease.

Executive Director of The George Institute Australia, co-author Prof.

The REMOVAL trial is the largest clinical trial of metformin therapy in type 1 diabetes to date and has provided clinically meaningful data on metformin's potential to reduce the risk of developing cardiovascular disease.

Canagliflozin, known as a SGLT2 inhibitor, is a relatively new type of drug that works by blocking the body's reabsorption of sugar or glucose.

"Care is warranted in the use of canagliflozin in patients at risk for amputation", a New England Journal of Medicine article on the study said. This causes in more glucose being released in the urine which thereby reduces the glucose levels of blood. Less positive was a doubling in risk of amputations associated with canagliflozin use.

It is recommended by watchdog NICE for patients for whom diet and exercise are not sufficient to keep blood sugar down, and for whom a much more common drug called metformin does not work. A warning of increased amputation risk was added to Invokana's prescribing label after it was discovered by safety monitors during an interim analysis of the study.

Related Articles

  • Sears Canada raises doubt about ability to continue, posts $144.4-million loss

    Sears Canada raises doubt about ability to continue, posts $144.4-million loss

    The company's current plight stems from a shortfall in a plan to borrow as much as $175 million, using real estate as collateral. Sears Canada also postponed its annual meeting, which had been scheduled for Wednesday, until an unspecified date.

    Trump's friend Christopher Ruddy says President 'considering' firing Mueller

    Bush administration, when Mueller was Federal Bureau of Investigation director and Comey was deputy attorney general. Mueller and former Federal Bureau of Investigation director James Comey worked closely for years in the George W.
    FM to meet PSU bank chiefs today to review NPA situation

    FM to meet PSU bank chiefs today to review NPA situation

    Uttar Pradesh and Maharashtra have already announced farm loan waive for farmers. "That's the part of the overall demand in the economy also".
  • Theater refuses to buckle after 'Caesar' Trump criticism

    Theater refuses to buckle after 'Caesar' Trump criticism

    The companies cut ties with the show because of its Trump-like Caesar (the character is assassinated in Shakespeare's play). The Public Theater and the White House did not immediately respond to requests for comment on Sunday.

    Ex-FBI Director James Comey visits hometown, dad

    He said Trump reached out to him again after the inauguration but he refused to call back, shortly before he was sacked . Comey said Lynch told him "not to call it an investigation but to call it a matter, which confused me and concerned me".
    Trump travel ban dealt another blow as appeals court rules

    Trump travel ban dealt another blow as appeals court rules

    Attorney General Jeff Sessions insisted the new decision would harm national security - an argument the judges rejected. The state urged the justices to deny an administration plea to reinstate the policy after lower courts blocked it.
  • Trump invited to testify about interactions with Comey

    Trump invited to testify about interactions with Comey

    But Comey believed that he was sacked because of his investigation into Russia's ties to the Trump campaign. He also said he hoped that Trump had taped their conversation and would, in turn, release them publicly.
    Suspected NKorea drone photographed US missile-defense site

    Suspected NKorea drone photographed US missile-defense site

    North Korea has touted its drone program in recent years, and South Korean officials believe its military has about 300 drones. It was similar in size and shape to a North Korean drone found in 2014 on an island near the border.
    Sessions to Testify Before Senate Intelligence Committee on Russia Probe

    Sessions to Testify Before Senate Intelligence Committee on Russia Probe

    The hearing will bring contentious questioning for Sessions and likely some uncomfortable moments for the Trump administration. Several lawmakers, especially Democrats , asked the leaders of the committee to insist it be open to the public and the press.
  • Turkey's Erdogan slams 'inhumane' isolation of Qatar

    Until then, Qatar had imported most of its dairy products from neighbouring countries - including Saudi Arabia . On Sunday Saudi Arabia's arch-rival Iran announced it had sent five planes carrying produce to Qatar.
    Theresa May to finalise cabinet amid DUP talks

    Theresa May to finalise cabinet amid DUP talks

    However, although their campaign may have been well co-ordinated, Jeremy Corbyn's arm was not. I think probably before this election you could have assumed it was going to happen.

    Warriors put away Cavs, claim second title in three years

    In last year's championship series the Cavs roared back from a 3-1 deficit to spoil the Warriors' record-setting 73-win season. Durant was named MVP of the finals, 10 years after being taken second overall in the National Basketball Association draft.