FDA Approves First Drug for BRCA-Mutated Breast Cancer

FDA Approves First Drug for BRCA-Mutated Breast Cancer

For women with a mutation whose breast tumors were also triple-negative-which refers to the lack of three specific characteristics seen in a breast tumor-their odds of long-term survival was the same, too.

"In view of this, younger women with breast cancer can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk reducing strategy", said Fiona MacNeill, a breast surgeon at The Royal Marsden National Health System Foundation Trust in Britain, which was not involved in the study.

The women's medical records were tracked for up to 10 years. The primary outcome was overall survival for all BRCA1 and BRCA2 mutations carriers compared with all non-carriers at 2, 5, and 10 years post-diagnosis. About 45 percent of women with faulty BRCA2 genes will.

The study recruited young women with breast cancer between the years 2000 and 2008, when BRCA testing and risk-reducing surgery were not routine for early breast cancer (stage one or stage two). About 12 percent of women are diagnosed with breast cancer at some point in their life.

Younger women diagnosed with breast cancer who carry a faulty BRCA gene are at no more risk of dying early than those without the mutation, according to a United Kingdom study.

Most of the women (89 percent) received chemotherapy, 49 percent had breast-conserving surgery, 50 percent had a mastectomy, and less than 1 percent had no breast surgery, according to the report.

Two notorious genetic mutations linked with breast cancer may not impact how long a woman will survive, a new study has found.

BRCA mutations are inherited and occur in either the BRCA1 or BRCA2 gene.

Women who carry a unsafe cancer gene have the same survival chances as other women with breast tumours, researchers have found. After 10 years, faulty gene carrier survival was 73.4% compared with 70.1% for non-carriers.

PALB2 - Works similarly to the BRCA genes.

Angelina Jolie made headlines when she underwent preventative surgery after learning she had an up to 87% chance of developing breast cancer.

BRCA mutations can cause cancer because the DNA self-repair mechanisms can malfunction.

"Decisions about timing of additional surgery to reduce future cancer risks should take into account patient prognosis after their first cancer, and their personal preferences", she added.

This is the finding of a prospective cohort study led by the University of Southampton, UK.

"Our data provides some reassurance that patients who are diagnosed with a BRCA gene fault as part of their cancer treatment journey can complete and recover from their breast cancer treatment, which is important", she said.

The researchers say that in the future this information could help women and their doctors make informed choices about treatment.

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